Mesothelioma Resources


Cases of Mesothelioma are set to increase – be prepared for quicker, non-invasive diagnosis


Can introducing an in vitro diagnostic test now help you identify those with previous exposure who are at risk?

We have compiled a bibliography of peer reviewed papers to provide you with independent evidence on how adding mesothelin can aid the diagnosis of malignant pleural mesothelioma:

  1. Huncharek M. (2002) Non-asbestos related diffuse malignant mesothelioma. Tumori. Jan-Feb;88(1):1-9.
  2. Montanaro F, et al. (2003) Pleural mesothelioma incidence in Europe: evidence of some deceleration in the increasing trends. Cancer Causes and Control. 14:791-803.
  3. Leigh J, Davidson P, Hendrie L, Berry D. (2002) Malignant mesothelioma in Australia 1945-2000. Am J Ind Med. 41:188-201
  4. Robinson BW, Creaney J, Lake R, et al. Mesothelin-family proteins and diagnosis of mesothelioma. Lancet. 2003; 362(9396):1612-1616.
  5. Scherpereel A, Grigoriu B. Conti M, et al. Soluble mesothelin-related peptides in the diagnosis of malignant pleural mesothelioma. Am J Respir Crit Care Med. 2006; 173(10):1155-1160.
  6. Beyer H, et al. MESOMARK™: A Potential Test for Malignant Pleural Mesothelioma. Clinical Chemistry. 2007:53(4);666-72.
  7. Cristaudo A, Foddis R, Vivaldi A, et al. Clinical significance of Serum Mesothelin in Patients with Mesothelioma and Lung Cancer. Clin Cancer Res. 2007;13(17):5076-5081.
  8. Di Serio F, Fontana A, Loizzi M, et al. Mesothelin family proteins and diagnosis of mesothelioma: analytical evaluation of an automated immunoassay and preliminary clinical results. Clin Chem Lab Med. 2007;45(5):634-636.
  9. Creaney J, Yeoman D, et al. Soluble mesothelin in effusions – a useful tool for the diagnosis of malignant mesothelioma. Thorax. 2007;62:569-576.
  10. Creaney J, van Bruggen I, Hof M, et al. Combined CA125 and mesothelin levels for the diagnosis of malignant mesothelioma. CHEST. July 2007. Published Online.
  11. van den Heuvel MM, Korse CM, Bonfrer JM, Baas P. Non-invasive diagnosis of pleural malignancies: The role of tumour markers. Lung Cancer. 2007, Oct 12. Published Online.
  12. Weber D.G., et al. Soluble mesothelin-related peptides (SMRP) – High stability of a potential tumor marker for mesothelioma. Cancer Biomarkers. 3(2007)287-292.
  13. Pass, H. I. et al. Soluble Mesothelin-Related Peptide level elevation in mesothelioma serum and pleural effusions. Ann Thorac Surg. 2008;85:265-272.
  14. Amati M, Tomasetti M, et al. Profiling Tumor-Associated Markers for Early Detection of Malignant Mesothelioma: An Epidemiologic Study. Cancer Epidemiol Biomarkers Prev. 2008;17(1):163-170.
  15. Creaney J, Yeoman D, et al. Comparison of Osteopontin, Megakaryocyte Potentiating Factor, and Mesothelin Proteins as Markers in the serum of patients with malignant mesothelioma. Journal of Thoracic Oncology.  2008;3(8):851-857.
  16. Jenette Creaney, Amanda Segal,  Nola Olsen,  Ian M. Dick, A. W(Bill) Musk, Steven J. Skates, and Bruce W. Robinson.  Pleural Fluid Mesothelin as an Adjunct to the Diagnosis of Pleural Malignant Mesothelioma. Disease Markers Volume 2014, Article ID 413946.
  17. Kazuya Fukuoka, Kozo Kuribayashi, Shusai Yamada, Kunihiro Tamura, Chiharu Tabata and Takashi Nakano. Combined serum mesothelin and carcinoembryonic antigen measurement in the diagnosis of malignant mesothelioma. Molecular and Clinical Oncology 1: 942-948, 2013
  18. A. Scherpereel. Diagnosis and staging of mesothelioma. DIAGNOSIS AND STAGING OF MESOTHELIOMA  Eur Respir Mon, 2009, 44, 392–406.
  19. Petra Smolkova et al. Validity of mesothelin in occupational medicine practice. International Journal of Occupational Medicine and Environmental Health 2016;29(3).
  20. Improved diagnosis of mesothelioma by a combination of soluble mesothelin-related peptide and CYFRA 21-1. Stefan Holdenrieder et al: J Lab Med 2015; 39(2): 103-113

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